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Appendices

The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.

Section 1. Active and Passive Immunization

ACTIVE IMMUNIZATION

Active Immunization of Persons Who Recently Received Immune Globulin

Live-virus vaccines given parenterally can have diminished immunogenicity when given shortly before or during a period of several months after receipt of immune globulins. High doses of immune globulin have been demonstrated to inhibit the response to measles vaccine for a prolonged period. The duration of inhibition varies directly with the dose of immune globulin administered. Inhibition of immune response to rubella, while of shorter duration than measles, also has been demonstrated. The appropriate suggested interval between immune globulin administration and measles immunization will vary with the indication for immune globulin (which determines the dose) and specific product (eg, Immune Globulin vs Immune Globulin Intravenous); suggested intervals are . . . [Go to Full Text]