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Appendices

The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.

Section 1. Active and Passive Immunization

ACTIVE IMMUNIZATION

Vaccine Handling and Storage

Inattention to vaccine storage conditions can contribute to vaccine failure. Certain vaccines, such as oral poliovirus (OPV) vaccine, measles, varicella, and yellow fever vaccines, are sensitive to increased temperature. Others are damaged by freezing; examples are diphtheria and tetanus toxoids and pertussis vaccines (DTaP [diphtheria and tetanus toxoids and acellular pertussis], DTP [diphtheria and tetanus toxoids and pertussis], DT [diphtheria and tetanus toxoids], and dT [diphtheria and tetanus toxoids]), inactivated poliovirus (IPV) vaccine, Haemophilus influenzae type b (Hib) conjugate, hepatitis A virus, hepatitis B virus, and influenza vaccines. Some products may show physical evidence of altered integrity, while others may retain their normal appearance despite a loss of potency. Therefore, all personnel responsible for handling vaccines in an office or clinic setting should be familiar with standard procedures designed to minimize the risk of vaccine failure. Recommended storage conditions for commonly used vaccines are listed in Table 1.4 (p 10). New vaccines and new formulations of currently available products may have storage requirements different from those listed in the Table. In addition, storage recommendations may be revised by the manufacturer. Revisions require approval by the US Food and Drug Administration (FDA).


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  		Table 1.4. Recommended Storage of Commonly Used Vaccines*
 

Recommendations for handling . . . [Go to Full Text]









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