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The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.
Section 1. Active and Passive Immunization
ACTIVE IMMUNIZATION
Scheduling Immunizations
A vaccine is intended to be administered to a person who is capable of an appropriate immunologic response and who likely will benefit from the protection given. However, optimal immunologic response for the person must be balanced against the need to achieve effective protection against disease. For example, pertussiscontaining vaccines may be less immunogenic in early infancy than in later infancy, but the benefit of conferring protection in young infants dictates that immunization should be given early despite a lessened serum antibody response. For this reason, in some developing countries, OPV vaccine is given at birth, in accordance with recommendations of the World Health Organization.
With parenterally administered live-virus vaccines, the inhibitory effect of residual specific maternal antibody determines the optimal age of administration. For example, live-virus measles vaccine in use in the United States provides suboptimal rates of seroconversion during the first year of life mainly because of interference by transplacentally acquired maternal antibody. If a measles-containing vaccine is administered before 12 months of age, the child should be reimmunized at 12 to 15
Related text in Red Book:
- Summary of Major Changes in the 2003 Red Book
Red Book 2003: xxv.[Extract] [Full Version] - Sources of Vaccine Information
Red Book 2003: 2-4.[Extract] [Full Version] - Immunizations Received Outside the United States
Red Book 2003: 34.[Extract] [Full Version] - Active Immunization of People Who Recently Received Immune Globulin
Red Book 2003: 35-36.[Extract] [Full Version] - Minimum Ages and Minimum Intervals Between Vaccine Doses
Red Book 2003: 23-32.[Extract] [Full Version] - Simultaneous Administration of Multiple Vaccines
Red Book 2003: 33.[Extract] [Full Version] - Lapsed Immunizations
Red Book 2003: 33.[Extract] [Full Version] - Preterm and Low Birth Weight Infants
Red Book 2003: 66-68.[Extract] [Full Version] - Refugees and Immigrants
Red Book 2003: 92-93.[Extract] [Full Version] - International Travel
Red Book 2003: 93-98.[Extract] [Full Version] - Immunocompromised Children
Red Book 2003: 69-81.[Extract] [Full Version] - Children in Residential Institutions
Red Book 2003: 85-87.[Extract] [Full Version] - Medical Evaluation of Internationally Adopted Children for Infectious Diseases
Red Book 2003: 173-180.[Extract] [Full Version] - Actinomycosis
Red Book 2003: 189-190.[Extract] [Full Version] - Poliovirus Infections
Red Book 2003: 505-509.[Extract] [Full Version] - Tetanus (Lockjaw)
Red Book 2003: 611-616.[Extract] [Full Version] - Diphtheria
Red Book 2003: 263-266.[Extract] [Full Version] - Haemophilus influenzae Infections
Red Book 2003: 293-301.[Extract] [Full Version] - Hepatitis B
Red Book 2003: 318-336.[Extract] [Full Version] - Human Immunodeficiency Virus Infection
Red Book 2003: 360-382.[Extract] [Full Version] - Pelvic Inflammatory Disease
Red Book 2003: 468-472.[Extract] [Full Version] - Pertussis
Red Book 2003: 472-486.[Extract] [Full Version] - Standards for Child and Adolescent Immunization Practices
Red Book 2003: 795-797.[Extract] [Full Version] - 2003 Red Book Erratum, P. 796
Red Book 2003: E7.[Extract] [Full Version]
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