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Section 1. Active and Passive Immunization
PASSIVE IMMUNIZATION
Immune Globulin
Immune Globulin is derived from the pooled plasma of adults by an alcoholfractionation procedure. Immune Globulin consists primarily of the immunoglobulin (Ig) fraction (at least 96% IgG and trace amounts of IgA and IgM), is sterile, and is not known to transmit hepatotropic viruses, HIV, or any other infectious disease agent. Immune Globulin is a concentrated protein solution (approximately 16.5% or 165 mg/mL) containing specific antibodies in proportion to the infectious and immunization experience of the population from whose plasma it was prepared. Large numbers of donors (at least 1000 donors per lot of final product) are used to ensure inclusion of a broad spectrum of antibodies.
Immune Globulin is recommended for IM administration. Because some recipients experience local pain and most experience local discomfort, IG should be administered deep into a large muscle mass, usually in the gluteal region or anterior thigh of a child (see Site and Route
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