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The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.
Section 1. Active and Passive Immunization
PASSIVE IMMUNIZATION
Treatment of Anaphylactic Reactions
Personnel administering biologic products or serum should be prepared to recognize and treat systemic anaphylaxis. The medications, equipment, and competent staff necessary to maintain the patency of the airway and to manage cardiovascular collapse must be available immediately. Appropriate and timely transfer of a patient with anaphylaxis to a pediatric intensive care unit or a hospital emergency department may be necessary.
The emergency treatment of systemic anaphylactic reactions is based on the type of reaction. In all instances, epinephrine is the primary drug. Mild symptoms of pruritus, erythema, urticaria, and angioedema should be treated with epinephrine injected intramuscularly, followed by diphenhydramine, hydroxyzine, or other antihistamine given orally or parenterally (see Tables 1.11
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