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The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.
Section 3. Summaries of Infectious Diseases
Amebiasis
Clinical Manifestations
Etiology
Epidemiology
Diagnostic Tests
Treatment
1
Isolation of the Hospitalized Patient
Control Measures
CLINICAL MANIFESTATIONS: Clinical syndromes associated with Entamoeba histolytica infection include noninvasive intestinal infection, intestinal amebiasis, ameboma, and liver abscess. Disease is more severe in the very young, the elderly, and pregnant women. Patients with noninvasive intestinal infection may be asymptomatic or may have nonspecific intestinal tract complaints. People with intestinal amebiasis (amebic colitis) generally have 1 to 3 weeks of increasingly severe diarrhea progressing to grossly bloody dysenteric stools with lower abdominal pain and tenesmus. Weight loss is common, and fever occurs in one third of patients. Symptoms may be chronic and may mimic inflammatory bowel disease. Progressive involvement of the colon may produce toxic megacolon, fulminant colitis, ulceration of the colon and perianal area and, rarely, perforation. Progression may occur in patients inappropriately treated with corticosteroids or antimotility drugs. An ameboma may occur as an annular lesion of the cecum or ascending colon that may be mistaken for colonic carcinoma or as a tender extrahepatic mass mimicking a pyogenic abscess. Amebomas usually resolve with antiamebic therapy and do not require surgery.
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In a small proportion of patients, extraintestinal disease may occur. Although the liver is the most common extraintestinal site, the lungs, pleural space, pericardium, brain, skin, and genitourinary tract also may be involved. Liver abscess may be acute with fever, abdominal pain, tachypnea, liver tenderness, and hepatomegaly or chronic with weight loss, vague abdominal symptoms, and irritability. Rupture of abscesses into the abdomen or chest may lead to death. Evidence of recent intestinal infection usually is absent.
ETIOLOGY: Entamoeba histolytica has been reclassified into 2 species that are morphologically identical but genetically distinct protozoa. The pathogenic E histolytica and the nonpathogenic
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Related text in Red Book:
- Drugs for Parasitic Infections
Red Book 2003: 744-770.[Extract] [Full Version]
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