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The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.
Section 4. Antimicrobial Agents and Related Therapy
INTRODUCTION
Fluoroquinolones
Use of fluoroquinolones (for example, ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, sparfloxacin, and trovafloxacin) generally is contraindicated, according to FDA-approved product labeling, in children and adolescents younger than 18 years of age, because fluoroquinolones have been shown to cause cartilage damage in every juvenile animal model tested at doses that approximate those needed to be therapeutic. The mechanism
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