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The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.

The first 20% of the full text of this section appears below.

Section 1. Active and Passive Immunization

PASSIVE IMMUNIZATION

Immune Globulin (Intramuscular)

Immune Globulin (intramuscular) is derived from the pooled plasma of adults by an alcohol-fractionation procedure. Immune Globulin consists primarily of the immunoglobulin (Ig) fraction (at least 96% IgG and trace amounts of IgA and IgM), is sterile, and is not known to transmit hepatotropic viruses, HIV, or any other infectious disease agents. Immune Globulin is a concentrated protein solution (approximately 16.5% or 165 mg/mL) containing specific antibodies that reflect the infectious and immunization experience of the population from whose plasma the IG was prepared. Many donors (at least 1000 donors per lot of final product) are used to include a broad spectrum of antibodies.

Immune Globulin is licensed and recommended for IM administration. Therefore, IG should be administered deep into a large muscle mass, usually in the gluteal region or anterior thigh of a child . . . [Go to Full Text]


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