| The first 300 words of the full text of this section appear below. |
Section 1. Active and Passive Immunization
IMMUNIZATION IN SPECIAL CLINICAL CIRCUMSTANCES
Immunocompromised Children
Primary and Secondary Immune Deficiencies
 Top Next |
|---|
The safety and effectiveness of vaccines in people with immune deficiency are determined by the nature and degree of immunosuppression. Immunocompromised people vary in their degree of immunosuppression and susceptibility to infection. Immunocompromised children represent a heterogeneous population with regard to immunization. Immunodeficiency conditions can be grouped into primary and secondary (acquired) disorders. Primary disorders of the immune system generally are inherited, usually as single-gene disorders; may involve any part of the immune defenses, including B-lymphocyte (humoral) immunity, T-lymphocyte (cell)-mediated immunity, complement, and phagocytic function as well as other, unique abnormalities of innate immunity; and share the common feature of susceptibility to infection. 1 Secondary disorders of the immune system are acquired and occur in people with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) or malignant neoplasms; people who have undergone transplantation or splenectomy; people receiving immunosuppressive, antimetabolic, or radiation therapy; and people with a variety of other illnesses, such as severe malnutrition, protein loss, and uremia (see Table 1.14, p 73). Published studies of experience with vaccine administration in immunocompromised children are limited. In most situations, theoretic considerations are the primary guide to vaccine administration, because experience with specific vaccines in people with a specific disorder is lacking. However, considerable experience in HIV-infected children provides reassurance about the low risk of adverse events in these children after immunization.
|
LIVE VACCINES. In general, people who are
Related text in Red Book:
         |
| Site Requirements | Privacy Policy | Core Values, Vision, and Mission Statement | ||
| The recommendations in this online publication do not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate. | ||
| Copyright © 2006 American Academy of Pediatrics |  |
|
