ad
This Article
Right arrow Images Only
Right arrow Full Version
Services
Right arrow E-mail this link to a friend
Right arrow Related text in Red Book
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Articles in Pediatrics
Right arrow reprints & permissions
Right arrow Section 1
Section 2
Section 3
Section 4
Section 5
Appendices

The following text is from an archived Red Book® edition and may not reflect current recommendations or information. To view the current edition, click here.

The first 20% of the full text of this section appears below.

Section 3. Summaries of Infectious Diseases

Rotavirus Infections

Clinical Manifestations
Etiology
Epidemiology
Diagnostic Tests
Treatment
Isolation of the Hospitalized Patient
Control Measures

Top
 Next
CLINICAL MANIFESTATIONS: Infection causes nonbloody diarrhea, often preceded or accompanied by vomiting and fever. Symptoms generally persist for 3 to 8 days. In severe cases, dehydration, electrolyte abnormalities, and acidosis may occur. In immunocompromised children, including children with human immunodeficiency virus infection, persistent infection and diarrhea can develop.


Top
 Previous
Next
ETIOLOGY: Rotaviruses are segmented, double-stranded RNA viruses belonging to the family Reoviridae, with at least 7 distinct antigenic groups (A through G). Group A viruses are the major causes of rotavirus diarrhea worldwide. Serotyping is based on the VP7 glycoprotein (G) and VP4 protease-cleaved hemagglutinin (P); G types 1 through 4 and 9 and P types 1A and 1B are most common.


Top
 Previous
Next
EPIDEMIOLOGY: Most human infections result from direct or indirect contact with infected people. Rotavirus is present in high titer in stools of infected patients with diarrhea, which is the only body specimen consistently positive for the virus. Rotavirus can be detected in stool before onset of diarrhea and may persist for as long as 21 days after the onset of . . . [Go to Full Text]


Related text in Red Book:

Children in Out-of-Home Child Care

Red Book 2006: 130. [Extract] [Full Version]  



This topic has been referenced by these articles:

  • Rennels, M. B. (2000). The Rotavirus Vaccine Story: A Clinical Investigator's View. Pediatrics 106: 123-125 [Full Version]  
  • Bell, E. F. (2005). Preventing Necrotizing Enterocolitis: What Works and How Safe?. Pediatrics 115: 173-174 [Full Version]  
  • Kombo, L. A., Gerber, M. A., Pickering, L. K., Atreya, C. D., Breiman, R. F. (2001). Intussusception, Infection, and Immunization: Summary of a Workshop on Rotavirus. Pediatrics 108 : e37-e37 [Abstract] [Full Version]  
  • Haber, P., Chen, R. T., Zanardi, L. R., Mootrey, G. T., English, R., Braun, M. M., the VAERS Working Group, (2004). An Analysis of Rotavirus Vaccine Reports to the Vaccine Adverse Event Reporting System: More Than Intussusception Alone?. Pediatrics 113: e353-e359 [Abstract] [Full Version]  
  • Iwamoto, M., Saari, T. N., McMahon, S. R., Yusuf, H. R., Massoudi, M. S., Stevenson, J. M., Chu, S. Y., Pickering, L. K. (2003). A Survey of Pediatricians on the Reintroduction of a Rotavirus Vaccine. Pediatrics 112: e6-10 [Abstract] [Full Version]