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Appendices

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Section 1. Active and Passive Immunization

Passive Immunization

Immune Globulin (Intramuscular)

IG (IM) is derived from pooled plasma of adults by an alcohol-fractionation procedure. IG consists primarily of the immunoglobulin (Ig) fraction (at least 96% IgG and trace amounts of IgA and IgM), is sterile, and is not known to transmit hepatotropic viruses, HIV, or any other infectious disease agents. IG is a concentrated protein solution (approximately 16.5% or 165 mg/mL) containing specific antibodies that reflect the infectious and immunization experience of the population from whose plasma the IG was prepared. Many donors (at least 1000 donors per lot of final product) are used to include a broad spectrum of antibodies.

IG is licensed and recommended for IM administration. Therefore, IG should be administered deep into a large muscle mass, usually in the gluteal region or anterior thigh of a child (see Site and Route of Immunization, p 18. . . [Go to Full Text]


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