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Section 1. Active and Passive Immunization
Immunization in Special Clinical Circumstances
Active Immunization After Exposure to Disease
Because not all susceptible people receive vaccines before exposure, active immunization may be considered for a person who has been exposed to a specific disease. The following situations are the most commonly encountered (see the disease-specific chapters in Section 3 for detailed recommendations).
Measles. Live-virus measles vaccine given to susceptible (ie, lack of antibody or receipt of fewer than 2 doses of measles virus-containing vaccine after 12 months of age) immunocompetent children 12 months of age and older, adolescents, and adults within 72 hours of exposure will provide protection against measles in some cases (see Measles, p 444). Determining the time of exposure may be difficult, because measles can be spread from 4 days before to 4 days after onset of the rash.
Immune Globulin (IG), administered intramuscularly within 6 days of exposure, also can prevent or attenuate measles in an immunocompetent or immunocompromised susceptible person (see
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