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Section 3. Summaries of Infectious Diseases
Rat-Bite Fever
Clinical Manifestations|
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CLINICAL MANIFESTATIONS
Rat-bite fever is caused by Streptobacillus moniliformis or Spirillum minus. S moniliformis infection (streptobacillary fever or Haverhill fever) is characterized by fever, rash, and arthritis. There is an abrupt onset of fever, chills, muscle pain, vomiting, headache, and occasionally, adenopathy. A maculopapular or petechial rash develops, predominantly on the extremities including the palms and soles, typically within a few days of fever onset. The bite site usually heals promptly and exhibits no or minimal inflammation. Nonsuppurative migratory polyarthritis or arthralgia follows in approximately 50% of patients. Untreated infection usually has a relapsing course for a mean of 3 weeks. Complications include soft tissue and solid-organ abscesses, pneumonia, endocarditis, myocarditis, and meningitis. Disease can be severe or even fatal in infants younger than 3 months of age. The case-fatality rate is 7% to 10% in untreated patients. With S minus infection, a period of initial apparent healing at the site of
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