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Image of the Week for July 3, 2009

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Prion Diseases, Transmissible Spongiform Encephalopathies

Prion Diseases, Transmissible Spongiform Encephalopathies. Histopathologic changes in frontal cerebral cortex of the patient who died of variant Creutzfeldt-Jakob disease in the United States. Marked astroglial reaction is shown, occasionally with relatively large florid plaques surrounded by vacuoles (arrow in inset) (hematoxylin and eosin stain, original magnification ×40).

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